June 7, 2017
Researchers from OICR and other institutions have created a new software program called EAGLE that mines data to understand the interactions between a person’s environment and their genetics. The tool has far-reaching uses, including oncology, and can provide researchers and clinicians with important information that can help personalize treatments for patients.
To learn more we spoke to Dr. Hillary Edgington, a Postdoctoral Fellow in OICR’s Informatics technology platform, which is led by Dr. Lincoln Stein. Edgington and her collaborators recently shared their research in the journal Nature Methods.
June 5, 2017
Fleming’s Biotechnology-Advanced students have received a significant boost to their career preparation with the help of The Ontario Institute for Cancer Research (OICR). Their investment in people is recognized through a very generous donation of an Illumina HiSeq DNA Sequencer to the Biotechnology-Advanced program, a benefit to Fleming College valued at $600,000. This new equipment will provide students with hands-on experience using cutting-edge automated instruments that are utilized widely across the biotechnology industry.
“Some of the best technicians in OICR’s genomic labs are Fleming College graduates. We are proud to pay-it-forward by helping the College give future life sciences researchers in Ontario hands-on training opportunities on real genomics equipment.” says Paul Krzyzanowski, Program Manager of Genome Technologies, OICR. “Illumina equipment is the backbone of most sequencing labs and it’s essential for today’s students to become familiar with the complexity around these machines with hands-on experience.”
The remarkable relationship between OICR and Fleming College has flourished over the last nine years. With its state of the art facilities and research, OICR has become a highly sought after internship agency for Fleming students since the first placement student in 2008. The support from OICR and Illumina helps Fleming College to lead the way in biotechnology training; contributing to excellence in academic programming that includes relevant experiences. The hands-on learning creates a positive impact towards the future of Fleming students and alumni, the success of employers and especially those who benefit from cancer research.
“We are very grateful for the Ontario Institute of Cancer Research for their investment in our students,” says Biotechnology Program Coordinator Ashvin Mohindra. “OICR provides a practical training component through their in-kind gifts and placement opportunities for our students. With their help, we are also pleased to meet OICRs employment needs which is proven with the hiring of more than 18 Fleming College graduates to fill their high-tech positions.”
The in-kind donation would have not been possible without the tireless effort of OICR and Illumina, the sequencer manufacturer and third party liquid handler software provider. The College would like to specifically recognize and thank everyone at OICR who made these donations possible (Lee Timms, Jessica Miller, Paul Krzyzanowski, Tom Hudson, Mike Kostiuk, Susan Hockley, Jeremy Johns, and Howard Simkevitz) and the staff at Illumina for their tireless help and expertise in setting up the equipment (Lisa Lock, Peter Ayache and Mike Ramsey).
OICR, a global leader in healthcare, research and innovation, is dedicated to exploring the prevention, early detection, diagnosis and treatment of cancer. Their commitment to exploring cancer extends beyond the lab; OICR invests in people who can make novel discoveries.
Note: This story originally appeared in the Spring 2017 edition of Fleming Ties magazine and has been reproduced with the permission of Fleming College. The original can be found here (PDF): https://flemingcollege.ca/PDF/FlemingTies/fleming-ties-spring-2017.pdf
May 3, 2017
The advent of genomic sequencing and targeted therapies has opened the door to new ways of diagnosing and treating cancer. The Ontario-wide Cancer Targeted Nucleic Acid Evaluation (OCTANE) program is a new, province-wide initiative supported by OICR that will allow more patients to benefit from these innovations while also helping to advance cancer research in Ontario.
April 13, 2017
Breast cancer is the most common form of cancer amongst women in Canada and worldwide, but despite its prevalence, a group of researchers believes that it should often be treated as a rare disease. Doing so would change clinical approaches and improve treatment for patients.
April 4, 2017
For three science-obsessed high school students March Break wasn’t a time to kick back and relax. Instead the students, Cameron, Chris and Zev, spent the week at OICR gaining knowledge and hands on experience in genomics and bioinformatics as part of the Gene Researcher for a Week program.
March 29, 2017
Polymerase chain reactions (PCR) are one of the most common tools used in molecular biology labs worldwide. This technique allows researchers to amplify, or increase, the amount of DNA in a sample so that they have more to work with. To keep track of the original molecules from a sample, chemical ‘barcodes’ are added. While barcodes serve an important purpose they can lead to errors and interfere with results. To prevent these cross-reactions a small team of international researchers have devised an ingenious method to ‘hide’ the barcodes when needed, leading to increased sensitivity and more reliable results.
Continue reading – New approach improves sensitivity of DNA sequencing, producing more reliable results
March 16, 2017
Genetic tests are being used more commonly in the diagnosis of many types of cancer. However, there currently isn’t a highly accurate test that can identify men with aggressive forms of prostate cancer, making it more difficult to choose the most appropriate course of treatment.
March 9, 2017
New molecular barcode technology reduces error rate in genomic sequencing to 1 in 10,000
Toronto (March 9, 2017) – Researchers at the Ontario Institute for Cancer Research (OICR), together with international collaborators, have invented a technique to avoid a major problem with common laboratory techniques and improve the sensitivity of important cancer tests.
February 23, 2017
Digital Detection Tool Will Be Shared Freely Over the Web
Toronto, ON and Baltimore, MD (February 23, 2017) A research team from the United States and Canada has developed and successfully tested new computational software that determines whether a human DNA sample includes an epigenetic add-on linked to cancer and other adverse health conditions.
February 13, 2017
Keeping track of samples and organizing their associated data is a crucial part of the research process. Like many labs around the world, those at OICR were using a commercially available Laboratory Information Management System (LIMS) to perform this task. However, the researchers using it found that this tool placed far too many constraints on their work. So what did they do? They built their own in partnership with the Earlham Institute (EI) in the U.K. This collaboration has resulted in powerful, flexible and open source software called MISO (Managing Information for Sequencing Operations).
February 9, 2017
The ability to sequence and study the human genome and the genomes of different cancer types has allowed scientists to increase our understanding of the biology of these diseases. In turn this has helped to create new preventative strategies, diagnostic and prognostic tools as well as better treatments. But what if there was a way to make this information even more useful? An international group is working to establish a project that will do just that.
January 13, 2017
What does a beaver’s genome look like? And how can understanding the beaver genome help us to improve human health? A group of Canadian researchers led by Drs. Stephen Scherer and Si Lok at The Centre for Applied Genomics and The Hospital for Sick Children today published the sequenced genome of the Canadian beaver in order to answer these questions and others (and just in time for Canada’s 150th anniversary, no less).
Dr. Jared Simpson led a team at OICR who provided their bioinformatics expertise on the project. We spoke to Simpson about his team’s role in the study and how their findings could contribute to a better understanding of cancer.