December 13, 2018

What can we gain from looking at the outliers?: An investigation into long and short-term ovarian cancer survivors

Kayla Marsh, a Research Technician, wiorks at a bench in the OICR-PM Translational Genomics Laboratory.

Researchers investigate the clinical, molecular and microenvironment factors that contribute to extreme therapy response and resistance in ovarian cancer patients

Some patients with high-grade serous ovarian cancer (HGSOC) respond exceptionally well to therapy, while others experience rapid disease relapse. The mechanisms behind these disparate outcomes are poorly understood, but a group of researchers based at the Princess Margaret Cancer Centre (PM) supported by OICR’s Ovarian Cancer Translational Research Initiative (TRI) are working to change that.

Continue reading – What can we gain from looking at the outliers?: An investigation into long and short-term ovarian cancer survivors

November 14, 2018

Blood samples over biopsies: Developing a less invasive way to find and track cancers

A lab technician works to extract DNA from a sample in OICR's Genomics lab.

Researchers find a new way to detect small traces of tumour DNA in blood and determine the tumour’s tissue of origin

A blood sample can be used to detect and monitor certain cancers in select patients, but there are significant technical barriers that prevent the widespread adoption of this “liquid biopsy”. This type of blood test analyzes the rare traces of tumour DNA that are circulating in the blood, but distinguishing tumour DNA from healthy DNA is both difficult and expensive. New methods are needed to improve the accuracy, sensitivity and cost-effectiveness of liquid biopsies so that more patients can benefit from this less-invasive test.

Continue reading – Blood samples over biopsies: Developing a less invasive way to find and track cancers

October 2, 2018

Understanding how cancer differs between sexes

Connie Li

OICR researchers uncover sex-linked genetic differences that may be able to predict cancer severity and response to therapy

Cancer differs in males and females but the origins and mechanisms of these sex differences remain unresolved. A better understanding of sex-linked differences in cancer could lead to more accurate tests and treatments that are personalized for patients based on their sex.

Continue reading – Understanding how cancer differs between sexes

September 4, 2018

Meet our students – 2018

Meet Dike Aduluso-Nwaobasi, Sarah Donald and Benson Wan. Find out how summer co-op positions affected their career and educational journeys.

August 22, 2018

Heliotrope: Personalizing cancer treatment decisions

Justin Cook poses for a photo in his office

OICR-developed software tool, Heliotrope, gains attention from the private sector for its potential to analyze large amounts of genomic information and inform clinical decision making

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August 21, 2018

Leader in data access and CEO of DNAstack, Dr. Marc Fiume, joins OICR as its newest Associate

Dr. Marc Fume poses for a photo in an atrium

Formalizing his longstanding relationship with OICR, Dr. Marc Fiume joins the Institute as an Associate to turn big data into a cure

“We know there are valuable – potentially life-saving – genomics and clinical data that are locked away in the sever rooms in hospital basements,” says Dr. Marc Fiume, CEO of DNAstack, Adjunct Professor at the University of Toronto, and OICR’s newest Associate. “We’re working to make these data more findable, accessible and useful to help researchers find cures for diseases faster than ever before.”

Continue reading – Leader in data access and CEO of DNAstack, Dr. Marc Fiume, joins OICR as its newest Associate

August 7, 2018

Data integration for the future of precision oncology

CDIC Banner images

Big data are ushering in a new era of individualized cancer care and prevention, but not without conceptual and practical challenges. Canadian advances in genomics will be made by or limited by bioinformatics analytical capacity as well as the ability to store and analyze data in new and more sophisticated ways.

To help realize the potential of genomics research in cancer, the Canadian Data Integration Centre (CDIC) platform, led by OICR, offers third generation bioinformatics and genomics tools to support both functional and clinical genomics research. CDIC is the largest academic cancer informatics program in the country – offering customizable, client-oriented access services for data challenges across diverse research areas.

Continue reading – Data integration for the future of precision oncology

June 13, 2018

Viral protein identified as one of the main drivers of virus-induced stomach cancers

The Epstein Barr virus in false Colour

Some common pathogens, like the Epstein-Barr virus (EBV), can turn healthy cells into cancer cells, but it is not well understood how they do so. Better understanding how such pathogens work allows researchers to find new ways to target the pathogen’s disease-causing mechanisms and ultimately find new treatments for certain virus-induced cancers.

Dr. Ivan Borozan, from Dr. Vincent Ferretti’s Lab at OICR, and Prof. Lori Frappier at the University of Toronto are working together to better understand EBV and how it triggers the transformation of normal cells to cancerous cells, also known as oncogenesis. Together, they have identified that a key protein expressed by EBV, BKRF4, is one of the likely drivers behind EBV-induced stomach cancers.

Continue reading – Viral protein identified as one of the main drivers of virus-induced stomach cancers

May 10, 2018

Symposium offers preview of findings from the Pan-Cancer Analysis of Whole Genomes project

PCAWG researchers pose for a group photo.

On April 13, researchers from around the world gathered at the MaRS Centre in Toronto to get a sneak peek at the findings from the Pan-Cancer Analysis of Whole Genomes (PCAWG) project. PCAWG is an ambitious international effort to comprehensively understand the non-protein coding elements of the genome, which make up 97 per cent of the genome but have been little studied in the context of cancer.

Continue reading – Symposium offers preview of findings from the Pan-Cancer Analysis of Whole Genomes project

March 29, 2018

Q and A with Dr. Philip Awadalla, Scientific Director of the Canadian Partnership for Tomorrow Project

Dr. Philip Awadalla poses for a photo in a hallway

Since 2008, the Canadian Partnership for Tomorrow Project (CPTP) has collected health data and biological samples from more than 300,000 volunteer participants across Canada. Now that its primary data collection phase has concluded, the Project is sharing this data with qualified researchers to help uncover the factors behind cancer and other diseases. It was recently announced that OICR’s Dr. Philip Awadalla will serve as the Project’s National Scientific Director and that OICR will host the Project’s national database and other scientific activities. We sat down with Awadalla to learn more about his vision for CPTP’s future. Continue reading – Q and A with Dr. Philip Awadalla, Scientific Director of the Canadian Partnership for Tomorrow Project

March 29, 2018

Canada’s largest health research platform teams up with University of Toronto to accelerate cancer and chronic disease research

The leaders of the CPTP stand in front of servers storing the Project's data.

Pictured (left to right): Dr. John Mc Laughlin, Executive Director of CPTP; Cindy Morton, Chief Executive Officer of the Canadian Partnership Against Cancer.; and Dr. Philip Awadalla, National Scientific Director of CPTP.

Canadian Partnership for Tomorrow Project (CPTP) enters a new era of scientific activity under the leadership of newly appointed National Scientific Director, Dr. Philip Awadalla

March 29, 2018 (Toronto) – The Canadian Partnership Against Cancer (“the Partnership”) today announced The University of Toronto’s Dalla Lana School of Public Health will be the new national scientific partner of the Canadian Partnership for Tomorrow Project (CPTP) – Canada’s national population cohort for precision health. This new scientific partner will enable a strong national scientific vision for CPTP and support leading-edge research on the possible causes of cancer and chronic diseases, leading to more made-in-Canada discoveries and breakthroughs. In addition, the University has announced that Ontario Institute for Cancer Research (OICR) will be its strategic partner to deliver the expertise and services needed to lead this key research platform.

Continue reading – Canada’s largest health research platform teams up with University of Toronto to accelerate cancer and chronic disease research

March 8, 2018

Collaborating to bring new treatment options to children with brain cancer

Medulloblastoma cells as seen under a microscope

OICR’s Brain Cancer Translational Research Initiative (TRI) and the Terry Fox Precision Oncology for Young People Program (PROFYLE) are partnering to share data and deliver improved treatment options to young brain cancer patients.

Continue reading – Collaborating to bring new treatment options to children with brain cancer

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