October 23, 2017

Boost your bioinformatics knowledge at TorBUG

Torbug - Lecture illustration

The Toronto Bioinformatics User Group’s (TorBUG) 2017-2018 season continues this Wednesday, October 23 with two presentations that promise to be of interest to anyone involved in bioinformatics. Dr. Quaid Morris, Associate Professor at the University of Toronto (U of T) will present “The Genetic Archaeology of Individual Cancers”. Brendan Innes, a PhD Candidate in the Bader Lab at U of T will cover “Cell types in single-cell RNAseq.”

Continue reading – Boost your bioinformatics knowledge at TorBUG

October 20, 2017

Old drug, new trick: study finds common diabetes drug could help fight leukemia

Researchers have discovered a new potential treatment for acute myeloid leukemia (AML). They found that boosting fat cells (adipocytes) within bone marrow with the use of a common diabetes drug slowed the growth of cancerous cells and promoted the regeneration of healthy blood cells.

Continue reading – Old drug, new trick: study finds common diabetes drug could help fight leukemia

October 18, 2017

GA4GH Strikes Formal Collaborations with 15 International Genomic Data Initiatives

Orlando, Florida (October 17, 2017) – The Global Alliance for Genomics and Health (GA4GH) has struck formal collaborations with 15 international genomic data initiatives as 2017 Driver Projects, including Genomics England, Australian Genomics and the U.S. All of Us Research Program. The announcement, made at the GA4GH 5th Plenary Meeting, comes as part of the launch of GA4GH Connect: A 5-year Strategic Plan. GA4GH Connect aims to drive uptake of standards and frameworks for genomic data sharing within the research and healthcare communities in order to enable responsible sharing of clinical-grade genomic data by 2022.

Continue reading – GA4GH Strikes Formal Collaborations with 15 International Genomic Data Initiatives

October 17, 2017

Global Alliance for Genomics and Health charts path to the future of genomic data sharing

Technology and DNA

The Global Alliance for Genomics and Health (GA4GH) has launched a new five-year strategic plan to develop international standards that will enable the responsible and secure sharing of genomic data for both scientific and clinical purposes. The plan, known as GA4GH Connect, was launched at the organization’s 5th Plenary Meeting in Orlando, Florida.  

Continue reading – Global Alliance for Genomics and Health charts path to the future of genomic data sharing

October 11, 2017

Ontario start-up makes major deal to develop cancer-fighting viruses

Partners congratulate Turnstone Biologics

Canadian academic institutions and research organizations are congratulating Turnstone Biologics on a new partnership with AbbVie to develop cancer-fighting viruses (also called oncolytic viral immunotherapies).

Turnstone was founded in Ottawa based on research led by Dr. John Bell (from The Ottawa Hospital and uOttawa), Dr. Brian Lichty (from McMaster University) and Dr. David Stojdl (from the Children’s Hospital of Eastern Ontario and uOttawa). The Ontario Institute for Cancer Research (OICR) and BioCanRx have also played a key role in advancing the technology.

Quick Facts and Links

  • Turnstone was recently recognized as one of the top 15 biotech start-ups in the world.
  • In 2016, Turnstone secured US$41 million in venture capital (VC) funding. This is believed to be the largest VC deal in Ottawa since 2013 and the second largest biotech VC deal in Canada in 2016.
  • As of October 2017, Turnstone had 25 employees in Ottawa, Hamilton and New York. It expects to approximately double its employees by the end of next year.
  • Turnstone’s most advanced product is called Ad-MG1-MAGEA3. It is produced in The Ottawa Hospital’s Biotherapeutics Manufacturing Centre and the McMaster Immunology Research Centre.
  • Top journal Science called cancer immunotherapy the “breakthrough of the year” in 2013.
  • Ad-MG1-MAGEA3 is currently being tested in clinical trials at several hospitals across Canada. People who are interested in participating in these trials can read these frequently asked questions.
  • While public funding is crucial for cancer research discoveries, private investment is almost always necessary to advance the development of new therapies, as this can cost more than US$2.5 billion.
  • Turnstone was co-founded by FACIT, The Ontario Institute for Cancer Research’s commercialization partner, which provided initial management, seed financing, intellectual property consolidation and hiring of initial employees including the CEO.
  • Numerous organizations have supported the research team, including the Alliance for Cancer Gene Therapy, Angels of Hope, BioCanRx, the Canada Foundation for Innovation, the Canadian Cancer Society Research Institute, the Canadian Institutes of Health Research, CHEO Foundation, Hair Donation Ottawa, the Ontario Institute for Cancer Research, the Ontario Ministry of Research, Innovation and Science, The Ottawa Hospital Foundation, the Ottawa Regional Cancer Foundation and the Terry Fox Research Institute.

Continue reading – Ontario start-up makes major deal to develop cancer-fighting viruses

October 4, 2017

FACIT Portfolio Company Fusion Pharmaceuticals Closes US$46M Oversubscribed Series A

Addition of new investors builds on Ontario’s next-gen radiotherapies and cancer innovations

Continue reading – FACIT Portfolio Company Fusion Pharmaceuticals Closes US$46M Oversubscribed Series A

October 4, 2017

New software uses machine learning to identify mutations in tumours without reference tissue samples 

DNA sequence

One of the main steps in analyzing cancer genomic data is to find somatic mutations, which are non-hereditary changes in DNA that may give rise to cancer. To identify these mutations, researchers will often sequence the genome of a patient’s tumour as well as the genome of their normal tissue and compare the results. But what if normal tissue samples aren’t available?

Continue reading – New software uses machine learning to identify mutations in tumours without reference tissue samples 

September 29, 2017

OICR 2016/17 Annual Report

OICR Annual Report 2016/17

We are pleased to share the Ontario Institute for Cancer Research (OICR) Annual Report for 2016/17.

We are living in an era of unprecedented innovation in cancer research. Recent advances have helped us to better understand cancer and allowed for collaboration on a scale that was previously not possible. This work is happening now and it is happening right here in Ontario.

Continue reading – OICR 2016/17 Annual Report

September 25, 2017

New study uncovers the role of mitochondrial DNA in prostate cancer

An image of mitochondria

Since mitochondria are inherited maternally, it may strike some as an odd place to go looking for connections to prostate cancer. But recently an international research team explored that relationship by looking at how the small amount of DNA contained in mitochondria, a cellular structure, is involved in prostate cancer.

Continue reading – New study uncovers the role of mitochondrial DNA in prostate cancer

September 15, 2017

Some braided it, some shaved it: the 2017 Terry Fox Great Canadian Hair Do!

OICR Hair do team - After

Since 2008 OICR staff members and others from the community have come together each year for the Terry Fox Great Canadian Hair Do, to raise money for important cancer research. This year the team raised more than $8,800 in support of the Terry Fox Foundation by shaving their heads or having their hair styled and brightly coloured. With these generous contributions the event has now raised more than $120,000 since its inception, and the team is still accepting donations.

Continue reading – Some braided it, some shaved it: the 2017 Terry Fox Great Canadian Hair Do!

September 6, 2017

OICR launches Tissue Portal to support tissue-based research projects

Fu Yan - In the lab.

OICR’s Tissue Portal is a new central entry and exit point for human tissue derived samples handled at OICR. This will serve as a gateway for tissue-based research projects to access over 100 services and resources at OICR being made available through the OICR Collaborative Research Resources on a cost-sharing basis. The Tissue Portal will standardize and streamline the storage, processing and distribution of samples for collaborative research studies at OICR.

Continue reading – OICR launches Tissue Portal to support tissue-based research projects

September 6, 2017

Ontario Tumour Bank collaborating to improve biobanking globally

Monique Albert

Biorepositories (or biobanks) play an important role in many types of research. But biobanking is a complex process requiring careful management of a whole range of scientific, legal, technical and ethical issues. We spoke to Monique Albert, Director of the Ontario Tumour Bank, about the importance of good biobanks, how the Ontario Tumour Bank is working with international partners to improve biobanking globally and why this type of international collaboration is benefitting researchers in Ontario.

Continue reading – Ontario Tumour Bank collaborating to improve biobanking globally